American and British scientists have identified two separate ?genetic signatures? for prostate cancer that they hope will predict the severity of the disease. If their hopes bear fruit, doctors will be able to predict with accuracy severe cases and treatment of the disease can be greatly improved.
News of these findings appear in two articles published recently in The Lancet Oncology. ?Both articles reveal distinctive patterns of RNA. That?s the genentic material that helps turn DNA into proteins. The patterns are said to tell whether patients have an aggressive prostate cancer or whether they have a milder form of the disease.
The authors of one article ( at The Institute of Cancer Research, London?and The Royal Marsden NHS Foundation Trust, UK) have identified a set of genes that were able to predict whether patients had castration-resistant prostate cancer. ?( Castration-resistant prostate cancer shows wide variation in survival times, though the reason is so far not clear.)
In the second article, researchers at Mount Sinai Medical School in New York identified a different set of genes with predictive properties similar to those in the British study.
Independent researchers say the scarcity of prognostic markers presents a major challenge for the clinical management of castration-resistant prostate cancer. And these latest results suggest that a few selected genes in blood samples from patients with castration-resistant prostate cancer can significantly improve the prediction of outcomes.? More work they say has to be done to better our understanding of the biological mechanisms at work here.
Source: http://www.prostatecancersurvivorspeak.com/blood-signatures-point-to-aggressive-prostate-cancer/
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