New weapons in the fight against cancer

ScienceDaily (Sep. 30, 2012) ? Several new first-in-human studies for drugs targeted against a range of cancers were released at the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna.

"These studies represent our first glance at some of the drugs that may improve cancer treatment in coming years," said Prof Ahmad Awada, head of the medical oncology clinic at Jules Bordet Institute, Brussels, Belgium, chair of the ESMO 2012 Developmental Therapeutics track. "Today's findings highlight the ways that clinical research is working on cancer therapies that target specific molecular pathways within tumor cells and their microenvironment. At ESMO 2012 this year, interesting early reports will be presented on MEK-, MET- and HSP90 inhibitors as well as studies on drugs targeting EGFR and PI3K and agents active in ALK-positive lung cancer resistant to crizotinib. In addition, new immunotherapeutic strategies and new generations of hormonal agents will be at the menu at this year's ESMO congress."

Key selected studies include: A proof-of-concept study of ODM-201 in patients with progressive castration-resistant prostate cancer

In a dose-escalation trial, 87% of 15 patients who received a novel androgen receptor agonist called ODM-201 experienced a PSA decrease at 12 weeks. "These early results are very promising, and such are rarely seen in these early trials. ODM-201 might be a new hormonal treatment option, and its efficacy-safety profile seems to be very promising in prostate cancer patients," said study author Dr Christophe Massard from Institute Gustave Roussy. "Unlike other anti-androgens, according to non-clinical data, ODM-201 has minimal or no brain entrance, and thus no testosterone increase in animal models. Therefore ODM-201 could be a promising new drug option for patients with metastatic or non metastatic prostate cancer. The results need to be confirmed in bigger patient population of course."

A dose-escalation study of oral selective c-Met inhibitor EMD 1214063 in patients with advanced solid tumors

The cell surface receptor tyrosine kinase c-Met is an emerging target for cancer treatment. EMD 1214063 is a highly selective, reversible and ATP-competitive c-Met inhibitor that causes growth inhibition and regression of HGF-dependent and HGF-independent tumors in pre-clinical models. This dose-escalation study is ongoing, with some preliminary evidence of clinical response being seen.

Multicenter study of the investigational drug TAK-733, an oral MEK inhibitor

Preliminary data of this trial in patients with advanced solid tumors indicate that TAK-733 is generally well tolerated and pharmacodynamically active with signs of anti-tumor activity in patients with advanced non-hematologic malignancies, say researchers.

Phase II study of HSP90 inhibitor AUY922 in patients with ALK-rearranged or EGFR-mutated advanced lung cancer

Among 121 patients with previously treated non-small cell lung cancer, activity was demonstrated in both ALK+ and EGFR-mutant patients, say investigators. Overall tumor response and progression-free survival rates observed warrant further studies, particularly among EGFR-mutant patients.

Results of a first-in-human study of the ALK inhibitor LDK378 in advanced solid tumors

Investigators report striking activity in ALK+ non-small cell lung cancer patients treated at doses over 400mg who had previously progressed following crizotinib.

Dose-finding study of the ALK/EGFR inhibitor AP26113 in patients with advanced malignancies

AP26113 was well tolerated with preliminary anti-cancer activity in ALK+ patients naive to, or failing, prior crizotinib, researchers say.

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The above story is reprinted from materials provided by European Society for Medical Oncology.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/-iZ69u5P2ZI/120930120757.htm

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Spain debt rises on aid to banks, regions, finance cost ? Firstpost

Sorry, Readability was unable to parse this page for content.

Source: http://financialupdate.org/?p=68822

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Paper: BP spill settlement talks stall as U.S. demands $18 bil

LONDON (Reuters) - Talks between BP and the U.S. government over a settlement for the 2010 oil spill have stalled because the U.S. is insisting that the British oil giant pay at least $18 billion, British newspaper the Sunday Times reported.

A settlement deal may not happen until early next year, the newspaper quoted sources close to the company as saying.

A settlement between $18 billion to $21 billion is near the level which BP would be required to pay should it be found grossly negligent under the Clean Water Act, said the paper.

BP, which declined to comment on the story, has always denied any liability for the United States' worst offshore environmental disaster.

Reports in July suggested that the U.S. was looking for a settlement of $25 billion.

The newspaper said that BP's board is split over whether to pay $18 billion or continue to push for a settlement at $15 billion, the level it is widely reported to be hoping to settle at.

(Reporting by Sarah Young; editing by Patrick Graham)

Source: http://news.yahoo.com/bp-spill-settlement-talks-stall-u-demands-18-130459854--finance.html

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Original 2007 Google-powered iPhone maps app reportedly built by 2 engineers in 3 weeks

I've read more than I ever wanted to about maps this week, but this story about how the original, Google-powered Maps.app was built for the original iPhone caught my attention. Here it s from Nick Wingfield and Brian X. Chen of The New York Times:

Including a maps app on the first iPhone was not even part of the company?s original plan as the phone?s unveiling approached in January 2007. Just weeks before the event, Mr. Jobs ordered a mapping app to show off the capabilities of the touch-screen device.

Two engineers put together a maps app for the presentation in three weeks, said a former Apple engineer who worked on iPhone software, and who declined to be named because he did not want to speak publicly about his previous employer. The company hastily cut a deal with Google to use its map data.

2 engineers. 3 weeks. Apple has spent the last year or more and who knows how many engineering hours trying to roll a new maps app. It looks nice, but iOS 6 Maps currently locates my house in the middle of a park, when I try to find a place to get my car rust proofed -- because winter is coming -- I get the wrong area code and a phone number that consists only of 443-0, and if I want to take a train downtown I suddenly need to buy an app for that.

Yet in 2007 Google's data was good enough for 2 Apple engineers to make a decent, if feature limited iPhone app in 3 weeks. That just goes to show you how important data quality is for something like maps, and how little a nice looking interface matters when you can't find something on it.

Apple's CEO, Tim Cook has already apologized for the current status of iOS 6 Maps, but not for taking away Google's much more reliable data. I don't expect him to either, any more than I expect Apple to apologize for dumping Safari RSS or X11.

People keep saying iOS 6 Maps will get better just by virtue of all of us using it. I'll correct my house, and use Google to find and correct the phone number of the anti-rust place (no idea how I can help fix the lack of train information though...) But it's going to take a lot more than me, or any of us, simply feeding Apple data to make a proper maps app. It's going to take Apple investing as heavily and determinedly as Google has over the last decade, but doing it much, much, much faster. It's going to take tons of money and a Herculean effort. Apple has tons of money. Let's hope Cook and company are serious about putting in the effort.

Until Apple mapping data is at least good enough for 2 engineers to build a pretty good app out of it in just 3 weeks...

Source: The New York Times

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Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/tn5KU9WlL1w/story01.htm

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8 Tips for Shopping at Home Centers

Consider the Combo Tool Packages

Think those combo packages tools are only good as Christmas gifts for those 20-something first-time homebuyers you know? Perhaps not?they could be a good deal for more people, like the handyman whose power-tool set has some miles on it and could stand for an overhaul. Sure, you might end up with a flashlight that you don't need, but you can also buy must-have tools, like a cordless drill, circular saw, and reciprocating saw together and save money versus buying them individually.

And the savings can be significant. Jason Swanson, director of communications for TTI Power Tool Group in Anderson, S.C. (which includes the Ryobi and Milwaukee tool brands), says you can save hundreds of dollars with combos. "You're not only buying a combo pack, you're getting into a system," he says. "You don't have to buy a charger and battery for each tool. You might spend $99 and get a $150 value. You can save a couple hundred dollars on a 6-pack of tools."

Pay Attention to Tool Details

Some tool brands are only sold at certain home centers, such as Rigid, available only at The Home Depot, and Kobalt, which sells at Lowe's. But brands that are available through multiple retailers sometimes have versions that are exclusive to a particular store chain. That means the brand of circular saw that's available at a home center may not be the same version that's sold at a tool outlet or on the manufacturer's website.

Do your research on tool specs including voltage, amps, accessories, and features to make sure you compare tools accurately, and not just by looking at price. For example, the Milwaukee M18 Lithium-ion 18-Volt Cordless 6-1/2 inch circular saw sold at The Home Depot for $119 is almost the same as the version sold at Northern Tool + Equipment for $350. But the latter version comes with two batteries and a charger, while The Home Depot version doesn't, which is a problem if you don't already have them.

Go to the Demos

Some DIYers stride into a home center feeling like Ron Swanson, ready to tell the cheerful staff, "I know more than you." But many home centers employ former contractors and tradespeople who can give expert advice. So listen. If you have a particular question, don't be shy about bringing in a picture of your room and asking for help. And the experts also provide in-store demonstrations, like how to install tile, in which they walk you through every step of a project with a lot of helpful tips that you won't get by reading manufacturer's instructions. The pros can also tell you exactly what tools and materials you need to complete a job and potential problems to watch out for.

Take Advantage of Store Programs

Already have a home center card? If so, it can help you keep track of purchases. That might sound a bit dubious, if you won't want stores having data on you, but it can actually be a benefit. For example, if you forgot the paint color used in your bathroom, scan your MyLowe's card in a store to find out the exact color. This makes "it simpler to remember what color a wall is painted or what size air filters are needed," says Tara Gudger, a spokesperson for Lowe's.

Other programs ensure the products you want are available when you need them. "When a customer places an order on lowes.com and selects ?Pick Up In Store ? Free' as the shipping option, the order is guaranteed to be ready at the store in 20 minutes," Gudger points out.

Be Leery of Code Advice

Although some home center employees know building codes from having worked in the field, others don't. An employee at my local home center, who asked not to be named, said store policy prohibits employees from giving advice on adhering to codes or saying what codes require. But some employees still do, and they can be wrong. For advice on codes, talk to building inspectors?they're also willing to help.

And Don't Assume Products Meet Codes

Just because a home center sells a product doesn't mean it meets local building codes. The stores may not know codes for your jurisdiction, especially new codes, and they sell products nationally. So the water heater package it sells may be acceptable in one area, but not another. It's up to you to know the codes and buy products accordingly. "The person doing the installation is responsible for making sure everything is up to code," an employee and former plumber at my local home center, who asked not to be named, told me. "That's why it's important to get a building permit?you'll know what's required to meet code."

Plan Ahead for Special Orders

Home centers offer a rich variety of products via their websites and special orders. If you just want a different sized vanity than what's in stock, the home center may be able to get it immediately from a local store. But products that need to be specially ordered could take a month or longer to arrive, so plan accordingly. You don't want to tear up your kitchen and then have a four-week hiatus waiting for the cabinets to arrive.

Cut Lumber Down to Size

For no cost or a small fee, home centers will cut or rip your lumber, making it easier for you to handle and fit in your vehicle. It'll also save you from having to handle and rip unwieldy large sheets of plywood on your own at home.

"It's a great benefit that can save you a lot of time and hassle, and it makes carrying the lumber a lot more convenient," an employee at my local home center told me. "We don't have to cut the lumber to its precise dimensions. We can make the cuts a little longer than what you need, then you can make the final cut at home."

Source: http://www.popularmechanics.com/home/improvement/interior/8-tips-for-shopping-at-home-centers-13145991?src=rss

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US Cellular expands its Windows Phone catalog with the ZTE Render for $80

Most Windows Phone enthusiasts have their sights set on large trophy-like targets, but if you have more modest goals in mind, then US Cellular's latest acquisition might be just what the doctor ordered. If the device pictured above looks familiar, that's because it should. Rebranded as the Render, most of you know this handset as the ZTE Orbit, an entry-level device that features a 4-inch 800 x 480 display, a 1GHz Qualcomm processor, 512MB of RAM, 4GB of internal storage, a 5-megapixel camera and Windows Phone 7.5 Tango. So, if US Cellular is your wireless carrier of choice and you're seriously crushing on Windows Phone, the ZTE Render will run you $80 after a $100 mail-in rebate.

Filed under: Cellphones, Mobile

US Cellular expands its Windows Phone catalog with the ZTE Render for $80 originally appeared on Engadget on Sat, 29 Sep 2012 12:13:00 EDT. Please see our terms for use of feeds.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/iCmPYQJIaGI/

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Georgia homeschool instructions

There are lots of main reasons why many parents choose to homeschooling their kids instead of benefiting from the traditional public or private educational method. One particular factors are philosophical, cost-effective, racial, non secular or governmental. A few mothers and fathers believe not open not private universities handle your meaningful belief program they really want involved in their children's education and learning. Various other mother and father cite 'utter discontentment together with either the particular programs or teacher's over-all knowledge? because factors behind home school their kids. Living Georgia with your loved ones and you are therefore studying the option of home school your young ones, permit me to direct you through the complete procedure. Georgia homeschool guidance contain both lawful as well as programs prerequisites that must end up being met in order for your young children in order to gain their own high-school level.

Georgia homeschool legal requirements

In line with the countrywide regulations of education and learning as well as the Atlanta office associated with Education, a young child must see college or be homeschooled until this extends to Sixteen yrs . old. If you plan to be a stay-at-home parent and you desire to home school your son or daughter, you need possibly high-school diploma or degree or perhaps GED. They are Georgia homeschool law. If you don't meet up with these kind of specifications, but you're even now determined for the home schooling make a difference, you could work with a tutor for your children. Another legitimate prerequisite will be the submission in the Commitment of Purpose. This is a yearly type which includes to be submitted simply no later than May 31st, as well as around Four weeks when you have began homeschooling. This Report have to be filled up with information on your own child's name, the age, the actual teacher, his/her informative abilities, the house address (the actual address of the house college), your designed course and also other extra-curriculum activities along with dates.

Georgia homeschool curriculum prerequisites

To meet this program specifications, educational routines must incorporate looking at, maths, technology reports, history of craft, words disciplines and sociable research. The the least a single academic evening is actually four and a half time associated with guidelines regarding A hundred and eighty days inside the total educational yr. The academic law connected with Atlanta obligates the tutor to help post attendance record over a every year base; whilst they assure you, it is for the top if you send it in monthly. Home-schooled youngsters likewise has to be sent to many forms involving assessments to enable your instructor to follow the development. After each and every academics calendar year, your child's trainer increases the standardised analyze which will be a rating software of their school achievement. Your instructor furthermore ought to distribute an evaluation report back to the actual Ga Office involving Schooling.

Georgia homeschool tutor's requirements

Regardless of your cause, realize that home school of one's youngsters is really a full time career. Which means that should you decide in order to commit yourself completely in your children's education and learning, it may need a large level of your time, this means you will need to approach as well as carry out each and every course, every single issue, every single activity, and each evening. If you can't do everything alone, you can make an attempt to question guidance - you can easily get the best Georgia homeschool instructor. All you have to perform can be question a few officials in the Ga Office involving Instruction for the list of homeschool trainers near your home regarding house. Make sure to verify the particular recommendations of most tutors and pick the correct one for your kids, because their training is just too big valuable to become put in vain.

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Writing about hair extensions and products, Narissa Drepaul aims to provide readers with informative knowledge into her experience gained within this area and offer readers the chance to view a website she has experienced positively.

Source: http://www.bestarticlepost.com/250174/georgia-homeschool-instructions?utm_source=rss&utm_medium=rss&utm_campaign=georgia-homeschool-instructions

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A Ray of Hope

Every day until the election,?Slate?will offer up one reason to be optimistic for your candidate.

But Romney has been here before. In his gubernatorial race in 2002, Romney was trailing his Democratic opponent Shannon O?Brien by 6 to 12 points in mid-October. His own polling had him 10 points behind. Romney was losing among women by 18 points. (Voters hadn?t taken a shine to his early ads that showed Mitt and Ann Romney talking about their prom.) But with four weeks to go, Romney hit O?Brien with ads attacking her for $7 billion in state pension fund losses, with images of a watchdog sleeping on the job. On Nov. 5, he became Massachusetts? Comeback Kid and won the election by 5 percent. (And hey, golfer Jack Nicklaus still believes in him.)

Source: http://feeds.slate.com/click.phdo?i=7d026963ec16fc69c81c7c692eb8e089

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FEMA trailer lawsuit settled for $42.6 million

David Friedman / NBC News

File photo shows a FEMA trailer park near Highway 90 in Bay St. Louis, Miss., in 2007.

By Mike BrunkerNBC News

More than six years after Gulf Coast victims of Hurricane Katrina began experiencing adverse health effects while living in travel trailers provided by the federal government for temporary housing, a federal judge in New Orleans has given his final approval to a $42.6 million settlement of a class-action lawsuit alleging that the units emitted hazardous levels of the toxic chemical formaldehyde.

U.S. District Judge Kurt Engelhardt approved the deal Thursday after hearing from attorneys who brokered the agreement between the plaintiffs and more than two dozen manufacturers of mobile homes provided by the Federal Emergency Management Agency in the wake of Hurricanes Katrina and Rita.

Roughly 55,000 residents of Louisiana, Mississippi, Alabama and Texas will be eligible for shares of $37.5 million paid by more than two dozen manufacturers, the Associated Press reported. They also can get shares of a separate $5.1 million settlement with FEMA contractors that installed and maintained the units.

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Dan Balhoff, a court-appointed special master, will determine the plaintiffs' awards, the AP said. Up to 48 percent of the total settlement money ? or approximately $20,5 million -- will be deducted for attorneys' fees and costs, it said. Assuming the remainder is divided equally among 55,000 plaintiffs, the plaintiffs would receive about $4,020 apiece.

Payments are expected to go out late this year or early next year, the AP said.

Engelhardt presided over three trials for claims against FEMA trailer manufacturers and installers after he was picked in 2007 to oversee hundreds of consolidated lawsuits. The juries in all three trials sided with the companies and didn't award any damages.

As msnbc.com (now NBCNews.com) first reported in July 2006, residents of the trailers began complaining of headaches, nosebleeds and breathing difficulty shortly after moving into the trailers, which were trucked to the Gulf Coast by the tens of thousands after Katrina and Rita devastated the area in rapid succession in 2005.

Air quality tests of 44 FEMA trailers in early 2006 conducted by the Sierra Club found formaldehyde concentrations as high as 0.34 parts per million ? a level nearly equal to what a professional embalmer would be exposed to on the job, according to one study of the chemical?s workplace effects.

And government tests on hundreds of trailers in Louisiana and Mississippi announced in 2008 found formaldehyde levels that were, on average, about five times what people are exposed to in most modern homes.?

FEMA, which isn't a party to the settlements, had long downplayed the health risks from formaldehyde exposure before those test results were announced.

It eventually began auctioning off the units as ?scrap? ? meaning they should not be used for human habitation ? in October 2008, but some unscrupulous buyers apparently were able to dodge regulations?and return them to the housing pool.?

Formaldehyde gas -- the airborne form of a chemical used in a wide variety of products, including composite wood and plywood panels in the travel trailers that FEMA purchased to house hurricane victims -- is considered a human carcinogen, or cancer-causing substance, by the International Agency for Research on Cancer and a probable human carcinogen by the EPA.

Gerald Meunier, a lead plaintiffs' attorney, told the AP that the deal provides residents with "somewhat modest" compensation but allows both sides to avoid the expense and risks of protracted litigation.

"Dollar amounts alone do not determine whether a settlement is fair and reasonable," he said.

Jim Percy, a lawyer for the trailer makers, said Engelhardt would have had to try cases individually or transfer suits to other jurisdictions if the settlement wasn't reached.

"It was not going to end quickly, and it was going to be even more monumental for all the parties concerned," he said.

But that doesn't mean the deal isn't a disappointment for many residents who blame their illnesses on the cramped trailers they occupied for months on end.

"We were told not to look for much," said Anthony Dixon, a New Orleans resident who says he developed asthma while living in a FEMA trailer for two years.

Dixon, 58, attended the hearing with his wife and mother to learn more about the deal.

"We're glad to get it over with," he added.

Engelhardt noted he received a letter from a woman whose 66-year-old mother, Agnes Mauldin, of Mississippi, died of leukemia in 2008 after living in a FEMA trailer. Mauldin's daughter, Lydia Greenlees, said the settlement offers "very little" for what her family considers to be a wrongful death case.

"I am saddened about the settlement in that I feel like it makes a mockery of my mother's life," Greenlees wrote. "I don't want anyone to think for one second that I view this settlement as a fair trade for my mother's life. I do not."

A group of companies that includes Gulf Stream Coach Inc., Forest River Inc., Vanguard LLC and Monaco Coach Corp. will pay $20 million of the $37.5 million settlement with the trailer makers.

Shaw Environmental Inc., Bechtel Corp., Fluor Enterprises Inc. and CH2M Hill Constructors Inc. are among the FEMA contractors that agreed to pay shares of the separate $5.1 million settlement.

Only a handful of formaldehyde-related claims are still pending, including some against FEMA by a group of Texas residents.

Mike Brunker is the projects editor for NBCNews.com; the Associated Press contributed to this article.

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Source: http://openchannel.nbcnews.com/_news/2012/09/28/14140222-class-action-suit-against-fema-trailer-manufacturers-settled-for-426-million?lite

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Penn St. officials lose pretrial motion on perjury

HARRISBURG, Pa. (AP) ? Two weeks before former Penn State assistant football coach Jerry Sandusky is expected to be sentenced on child molestation charges, a county judge determined that perjury charges should remain in place against two university administrators.

Dauphin County Judge Todd Hoover ruled Wednesday against former Vice President Gary Schultz and Athletic Director Tim Curley on the felony perjury charge they both face, but he didn't decide on a separate request to throw out the other charge ? failure to report suspected child abuse.

The perjury counts are felonies, while failure to report suspected child abuse is a summary offense, less serious than a misdemeanor. Schultz and Curley are accused of lying to the grand jury that investigated Sandusky.

The judge said the claim made by Schultz and Curley that there is insufficient evidence to corroborate the perjury charges will be more appropriately pursued during the trial. He also said prosecutors have given the defendants sufficient information about which parts of their grand jury testimony make up the perjury allegation.

"Having satisfied the request to specify the statements it will seek to prove as perjurious, we find that the commonwealth need not identify the manner in which it intends to prove the alleged falsity of each statement," the judge wrote.

Hoover did not say when he would rule regarding the failure to properly report suspected child abuse, for which Curley and Schultz have argued the statute of limitations has expired.

Schultz, the university's former vice president for business and finance, has retired. Curley, the athletic director, is on leave. Their trial is scheduled to begin in Harrisburg with jury selection on Jan. 7. Defense lawyers are seeking to split the criminal cases against them.

A spokesman for the attorney general's office declined to comment Wednesday. A spokeswoman for the defendants' lawyers did not immediately return messages seeking comment.

Sandusky, a former defensive coordinator, was convicted in June on charges he sexually abused 10 boys, some on campus. He remains jailed awaiting sentencing Oct. 9.

Eight young men testified against Sandusky, describing a range of abuse they said went from grooming and manipulation to fondling, oral sex and rape when they were boys and for some included acts that occurred in Penn State team showers. One young man testified that his muffled screams from the basement of the Sandusky home in State College, where Penn State's main campus is, went unanswered as Sandusky attacked him.

The 68-year-old Sandusky maintains his innocence, acknowledging he showered with boys but insisting he never molested them. Given his age and the serious nature of the crimes of which he was convicted, he's likely to receive a sentence that will keep him in prison for life.

The abuse scandal touched off by Sandusky's arrest last year rocked Penn State, bringing down longtime coach Joe Paterno and the university's president and leading the NCAA, college sports' governing body, to levy unprecedented sanctions against the university's football program.

Former FBI Director Louis Freeh, hired by university trustees to conduct an investigation into the university's handling of abuse complaints against Sandusky, concluded that Paterno, ousted President Graham Spanier, Curley and Schultz concealed a 2001 allegation against Sandusky to protect Penn State from bad publicity.

The late coach's family, as well as Spanier, Curley and Schultz, have hotly disputed Freeh's assertions.

Source: http://news.yahoo.com/penn-st-officials-lose-pretrial-motion-perjury-072005331--spt.html

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Green ideas for green manufacturing | Eco-Business.com

The Fujisawa City project in the Kanagawa Prefecture near Tokyo brought together nine companies and the government to develop an energy-smart community. Image: Panasonic

In this interview by Singapore?s Energy Market Authority, Panasonic Asia Pacific managing director Yorihisa Shiokawa reveals how manufacturers can contribute to an energy efficient society through innovation, collaboration and careful management.

Energy Market Authority: Panasonic?s ambition is to be the leading ?Green Innovation Company? in the electronics sector. What steps is Panasonic undertaking to achieve this target? What impact will this have on consumers and the environment?

Yorihisa Shiokawa: We want to become the number one Green Innovation Company in the electronics sector by 2018. Through our ?eco ideas? strategy, we create innovative businesses, products and services that are energy-efficient or have smart energy features, and therefore are more environmentally-friendly. But they also help consumers save money. We are on track to achieving 80 per cent of our total sales in Asia Pacific from these eco products.

Panasonic Group is also focused on developing Total Energy Solutions that involve energy creation, storage, savings and management. We set up the Panasonic Energy Solutions Development Centre Singapore in July this year to develop total energy solutions not only for the region, but also to commercialise them globally. Panasonic is working closely with the local authorities in Singapore to test-bed some of our urban solutions at the?Punggol Eco-Town project.

We have a Panasonic Eco Learning Programme, which will help 200,000 students across Asia Pacific to develop environmental awareness and an understanding of how virtually zero CO2 emissions can be achieved through technology. We will continue to spread the word so that more will come together to create a positive impact on the environment.

Panasonic applies the ?eco ideas? strategy to our own business. We aim to reduce the environmental impact of our business operations by making the best use of resources and energy through green innovation. We have set a goal of a 600,000-tonne CO2 reduction in our operations versus a ?business-as-usual? level (based on our fiscal year ending March 2005).

We are also developing three more ?eco ideas? factories by March 2013, which will demonstrate our sustainability solutions and capabilities. These factories adopt green solutions and exemplify how reductions in CO2 emissions, managing waste generation and chemical substance releases and maintaining energy efficiency can be achieved in manufacturing facilities.

EMA: In difficult economic times, some consumers may not be inclined to pay for green-certified appliances. What role can global manufacturers play in raising the awareness of the importance of such appliances?

YS: Global manufacturers can take the lead to help imbue eco-consciousness among consumers though championing environmental awareness programmes and education initiatives. Industry players must work with governments worldwide to ensure their products are compliant with the energy regulations of each country. In Singapore, Panasonic?s air conditioners and refrigerators meet the standards which are required for The Energy Label, mandated by the National Environment Agency (NEA).

Asia Pacific also has many environmental challenges in emerging and rapidly growing markets. Economic growth can create environmental pressures ? especially in creating and providing a stable supply of energy and meeting the demand for improved living standards. Product customisation for particular markets is important. In India, for example, the CUBE air-conditioner takes into account specific Indian climatic conditions and space limitations. This kind of product customisation will encourage customers to purchase green-certified appliances.

EMA: Businesses, especially manufacturing companies, are some of the biggest consumers of energy. How do you think businesses can and should conserve energy through their own business practices?

YS: Business growth must be achieved with an eye on conserving the planet for future generations. We are committed to promoting environmental sustainability and reducing the impact of our business operations. There are two ways to achieve this:

First, look at reducing CO2 emission. Panasonic has been using meters and gauges to manage energy consumption during production, as well as replacing fluorescent lights with energy-efficient Light-Emitting Diode (LED) lights in our factories. By doing so, we have been able to reduce CO2 emissions by 560,000 tonnes in our Asia-Pacific operations as of the end March this year.

Second, companies should set assessment criteria on the environmental impact of their products. This needs to be done right from the planning and design stage. Improved environmental performance can be based on criteria such as energy savings, resource savings and chemicals management.

EMA: There is much being said about public-private partnerships in developing solutions that lower energy consumption. How have Japanese companies, for instance, collaborated with the Japanese government to help meet nationwide energy intensity goals?

YS: In Japan, such collaborations are increasingly important for a nation that is dependent on imports of virtually all fossil fuels. For decades, Japanese energy policy has focused on efficiency, diversity and development of indigenous energy sources.

One such recent project is Fujisawa City in Kanagawa Prefecture, situated about 50km west of Tokyo. This collaboration sees nine companies coming together with the government to build an innovative smart town deploying services and energy systems based on Panasonic?s ?eco ideas? for green lifestyles. The companies include developers, manufacturers and service providers and will see an eventual actual operation of the town with about 1,000 households. The smart town is to be built on the vacant lot of Panasonic?s former factory site and is targeted to open in the fiscal year ending in March 2014.

Apart from these large-scale collaborations, there are other ways to contribute to the nation, especially in times of crisis. At the end of March 2011, Panasonic donated a Life Innovation Container to the Miyagi Prefecture, which suffered widespread devastation in the Great East Japan Earthquake. The container is a standalone power system equipped with solar panels and rechargeable batteries to deliver electricity to areas without access to electricity.

But such collaborations are picking up in other parts of Asia as well. For example in Singapore, we are partnering with the Housing Development Board (HDB), Energy Market Authority (EMA) and Economic Development Board (EDB) to test-bed total energy solutions on an existing public residential building in Punggol Eco-Town. This project aims to achieve zero CO2 emissions for common areas of public housing in Singapore, and provide residents with a complete total energy solutions package that helps monitor and better manage their energy consumption.

EMA: Do you think companies can combine making contributions to the environment with business growth? Do you think legislation, such as those enacted in Japan and soon to be enacted in Singapore, will push companies to be more energy-efficient?

YS: Our belief is that we must integrate environmental conservation with business growth.? As such, we strive to achieve the highest achievement levels in reducing CO2 emissions, recycling resources, the size of our energy systems business and the sales ratio of environmentally-friendly products. These are our ?Green Indexes? and they are just as important as our Global Excellence Indexes, which look at sales, operating profit and return of equity.

Legislation also has a role to play in driving mindset changes in energy consumption and the nation?s energy mix.? In July 2012, the Japanese government rolled out feed-in tariffs (FiTs) for renewable energy. The Japanese FiTs are significantly higher than those offered in both Germany and China. Such clean energy investments shift Japan?s reliance on nuclear energy. Government subsidies benefit solar panel makers such as Panasonic, spurring them to manufacture even more energy-efficient products and services.

We also applaud the Singapore government for introducing the Energy Conservation Act, which comes into effect in 2013, to improve energy efficiency across different sectors. It will also drive energy efficiency in business. The legislation requires factories that consume more than 15GWh of energy a year to implement minimum energy management standards, such as the appointment of an energy manager, reporting of energy use and submission of energy efficiency improvement plans.

This is likely to help households make more informed choices about purchasing energy-efficient appliances since the legislation stipulates the minimum energy performance standards and energy labelling scheme for common household appliances such as air-conditioners and refrigerators.

Yorihisa Shiokawa is Managing Executive Officer, Regional Head for the Asia Pacific, Middle East & Africa of Panasonic Corporation, as well as Managing Director of Panasonic Asia Pacific. He assumed his role from April 2011, after three decades of building the brand name Panasonic in markets such as Europe, notably its digital audio-visual product and home appliance businesses.

This article was originally published on the Singapore International Energy Week 2012 website, and has been republished with permission.

Source: http://www.eco-business.com/features/5qs-with-panasonics-yorihisa-shiokawa/

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Matrix One drops to $60, moves from impulse purchase to disposable tablet

Well, the Matrix One isn't becoming any more attractive spec-wise as the days pass, but Direct Merchandise Marketing believes they can keep up with the low-priced big boys by under-cutting them even further. If a $90 retail sticker wasn't enough to convince you that the A8-powered ICS slab deserved your attention, maybe a drop to $60 will change your tune. The 7-inch WVGA tablet is now an impressively thrifty $59.99, though, after tax and shipping the total tops $70. Still, its impossible to deny its bargain value.

Filed under: Tablets

Matrix One drops to $60, moves from impulse purchase to disposable tablet originally appeared on Engadget on Thu, 27 Sep 2012 06:33:00 EDT. Please see our terms for use of feeds.

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Video: More Market Drama in Q4?

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Erick Erickson's 'Elitist Conservative' Construct Makes No Sense (Atlantic Politics Channel)

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Debate Momentum Changer?

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Considering the Right Motor Boats for Sale

Nowadays, you can find motor boats for sale everywhere. You can find them in almost every local store in your area. In addition, you can find them in online stores in the internet if you do not want to go directly to the showroom. In the internet, you can browse any kinds of boats that you want to buy. You can always check the price and other things beforehand based on the types of boat that you want to procure. There are three kinds of boat that you can choose in local and online boat stores. They are new boats, used boats and luxury yacht.

New boats are the ones that are recently produced by the manufacturers. They are equipped with the newest features and technology that are invented recently. The boats are usually recommended by the sellers due to the newest features, which are comfortable and nice. It rarely happens for new boats to be sold in wholesale ways but there is still a possibility that new motor boats for sale will occur. Of course, there are reasons behind this. One of the reasons is to promote the new boats that a certain company produces. It can be used as an effective way to boost the selling points.

Used boats are boats that have been bought by other people beforehand. Some people may get bored with the boats that they own, and then they decide to sell them and buy a new one. You can find them in some local and online boat stores with a wide range of prices. Buying used boats has many advantages. One of them is that it saves a lot of money. Used boats cost much cheaper than the new ones. Besides, used motor boats for sale can often be found in the stores, both local and online stores.

Luxury yachts are boats that are made for rich and ?lite people. Since this kind of boat costs so much money, only hardcore boat enthusiasts with money can afford it. There are some ways to get this kind of boat. One of them is by hiring a broker. A broker can help you deal with financing, deal brokering, inspection arrangement, title clearing and procuring, docking space and yacht services for the luxury yacht you want to purchase. Moreover, there is also a place where you can have the service of a broker that will help you purchasing the luxury yachts you always dream of. This place is called Yachtcouncil. This place will also help you find a place for luxury motor boats for sale. However, it is rare for luxurious motor boats will be sold for sale, but there are some sales for luxury yachts that you can enjoy.

Looking for yacht to buy is a delicate process. There are some aspects that you should consider before purchasing the yachts you want. The first thing to consider is the type of the yacht you need. The one that is recommended is the hull type. However, there are two types of hull type: mono-hull and multihull. You can pick either one with the facilities and the risks that are offered by each of them. Nevertheless, this type of boat is the best type of boat nowadays, so you will find many more benefits than the risks. The second thing to concern about is the material used to produce the yachts you want to buy. The most common material that is used is GRP or Glass Reinforced Plastic. This material is well known for its lightness, durability, and cheapness. These are some characteristics you should really pay attention to when buying luxury yachts or motor boats for sale.

Source: http://www.artipot.com/articles/1386625/considering-the-right-motor-boats-for-sale.htm

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Ravens defeat Patriots 31-30 on late FG by Tucker

Baltimore Ravens tight end Dennis Pitta, left, celebrates his touchdown with teammates Jacoby Jones (12) and Torrey Smith, back, in the first half of an NFL football game against the New England Patriots in Baltimore, Sunday, Sept. 23, 2012. (AP Photo/Nick Wass)

Baltimore Ravens tight end Dennis Pitta, left, celebrates his touchdown with teammates Jacoby Jones (12) and Torrey Smith, back, in the first half of an NFL football game against the New England Patriots in Baltimore, Sunday, Sept. 23, 2012. (AP Photo/Nick Wass)

Baltimore Ravens fullback Vonta Leach, top, is upended by New England Patriots cornerback Devin McCourty as he rushes the ball in the first half of an NFL football game in Baltimore, Sunday, Sept. 23, 2012. (AP Photo/Nick Wass)

New England Patriots running back Stevan Ridley, center, attempts to rush past Baltimore Ravens cornerback Lardarius Webb, left, and linebacker Dannell Ellerbe in the first half of an NFL football game in Baltimore, Sunday, Sept. 23, 2012. (AP Photo/Nick Wass)

New England Patriots defenders tackle Baltimore Ravens wide receiver Deonte Thompson, bottom center, as he rushes the ball in the first half of an NFL football game in Baltimore, Sunday, Sept. 23, 2012. (AP Photo/Gail Burton)

New England Patriots wide receiver Julian Edelman (11) can't hold onto a pass attempt as he is pressured by Baltimore Ravens cornerback Cary Williams in the first half of an NFL football game in Baltimore, Sunday, Sept. 23, 2012. (AP Photo/Nick Wass)

BALTIMORE (AP) ? Operating with little sleep and much emotion, Torrey Smith played a magnificent game under the most difficult circumstances.

His teammates on the Baltimore Ravens helped Smith cope, then provided him a victory for his effort.

Rookie Justin Tucker kicked a 27-yard field goal as time expired, giving the Ravens a 31-30 victory over the New England Patriots on Sunday night in a rematch of the AFC championship game.

Playing less than 24 hours after his younger brother died in a motorcycle accident, Smith scored two touchdowns and caught six passes for 127 yards. Only hours earlier, he wasn't even sure if he would suit up.

"It was tough. I didn't know until 4 o'clock if I was going to play," Smith said. "I only had like an hour of sleep. Emotionally, I didn't know how I was going to hold up."

Smith left the team hotel at 1 a.m. Sunday to be with his family. Upon arriving at the stadium, the familiar surroundings helped Smith get ready to go.

"When I came here, the more I was grounded. The more comfortable I began to feel," he said. "I'm glad I came back up here. It helped me out a lot."

Coach John Harbaugh said: "If you're around athletics, I guess you feel like it's an escape, an opportunity to do what he does. He's being doing it his whole life; he knows what to do. When Torrey said he wanted to play, the decision was finished. He was going to get the opportunity to play, he deserved that."

A moment of silence was observed before the game for Smith's brother, 19-year-old Tevin Jones.

"It means a lot not just for us but for my family. ... That's for my little brother,'" Smith said.

When the teams met in January, the Patriots squeezed out a three-point win at home to advance to the Super Bowl. The stakes weren't nearly as high in this one, yet the game was eerily similar.

In the previous meeting, Billy Cundiff missed a 32-yard field goal in the closing seconds. In the encore, Tucker ? who took the job away from Cundiff in training camp ? drove his kick just inside the right upright.

The game-winning kick followed a pass interference call against Devin McCourty, who was covering Jacoby Jones.

As the officials were leaving the field, Patriots coach Bill Belichick grabbed one of them by the arm. He didn't pursue as the official continued to run off the field.

"I'm not going to comment on that," Belichick said. "You saw the game. What did we have, 30 penalties called in that game?"

Actually, 24, including 14 against the Ravens for 135 yards.

Baltimore (2-1) won its 12th straight at home behind Joe Flacco, who went 28 for 39 for 382 yards and three touchdowns.

Tom Brady completed 28 of 41 passes for 335 yards and a score for the Patriots (1-2), who fell below .500 for the first time since Week 1 of 2003.

"We didn't do what we needed to do to help our offense tonight," Patriots defensive tackle Vince Wolfork said. "And it (stinks), because coming into the game, I think we had a pretty good idea of how we wanted to play it. First quarter, it showed. It seems after that, we really couldn't get off the field. Offense played their tails off and we just left them out to dry. We can't do that."

New England led 13-0 after the first quarter and 30-21 with 14 minutes left, but couldn't make either lead stand up.

Wes Welker had eight catches for 142 yards and Brandon Lloyd caught nine passes for 108 yards for the Patriots, who fell to 6-1 against the Ravens in the regular season ? 7-2 including the playoffs.

Down 20-14, the Ravens opened the second half with an 80-yard drive that ended with a 7-yard touchdown run by Ray Rice. Brady matched that with an 80-yard march of his own, repeatedly picking on cornerback Cary Williams, before Danny Woodhead scored on a 3-yard run to put New England ahead.

After Stephen Gostkowski kicked his third field goal to make it 30-21, Smith caught a 5-yard touchdown pass with 4:01 left to get the Ravens to 30-28. Flacco went 6 for 7 for 76 yards in the 92-yard drive.

Baltimore executed the game-winning drive in the final 2 minutes.

New England took a 13-0 lead before the Ravens got their initial first down. Then, after Baltimore went up 14-13, Brady engineered a frantic touchdown drive at the end of the first half to put the Patriots back in front.

Welker, who came in with only eight catches in two games, played a key role for New England in the opening minutes. He recovered a fumble by Brady on the Patriots' second play, and on New England's second series Welker broke loose on the left sideline for a 59-yard completion that set up a 37-yard field goal.

The long pass to Welker pushed Brady into 12th place on the career yardage list, past Hall of Fame quarterback Joe Montana (40,551).

On the first play following the kickoff, Steve Gregory intercepted a pass by Flacco and took it 36 yards to the Baltimore 6. On third down, rookie Brandon Bolden ran in from the 2 for his first NFL touchdown.

Late in the first quarter, Gostkowski kicked a 49-yard field goal for a 13-0 lead.

After two three-and-outs and an interception, Flacco found his rhythm the fourth time he got the ball.

Flacco moved the Ravens 82 yards in 13 plays in a drive culminated by a 25-yard touchdown pass to Smith. Then, after a New England punt, Baltimore covered 92 yards in eight plays. The capper was a 20-yard TD pass to tight end Dennis Pitta, who hurdled Gregory inside the 10 before completing his romp into the end zone.

Brady answered with a touchdown pass of his own, a 7-yarder to Julian Edelman with 2 seconds left to cap an 81-yard, beat-the-clock march.

NOTES: Baltimore amassed 503 yards in offense. Rice ran for 101 yards on 20 carries. ... Edelman left with a hand injury. ... Baltimore punted only three times.

Associated Press

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"Face the Nation" transcripts, September 23, 2012: President Clinton (cbsnews)

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Fueling the fleet, U.S. Navy looks to the seas

ScienceDaily (Sep. 24, 2012) ? Refueling U.S. Navy vessels, at sea and underway, is a costly endeavor in terms of logistics, time, fiscal constraints and threats to national security and sailors at sea.

In Fiscal Year 2011, the U.S. Navy Military Sea Lift Command, the primary supplier of fuel and oil to the U.S. Navy fleet, delivered nearly 600 million gallons of fuel to Navy vessels underway, operating 15 fleet replenishment oilers around the globe.

From Seawater to CO₂

Scientists at the U.S. Naval Research Laboratory are developing a process to extract carbon dioxide (CO₂) and produce hydrogen gas (H₂) from seawater, subsequently catalytically converting the CO₂ and H₂ into jet fuel by a gas-to-liquids process.

"The potential payoff is the ability to produce JP-5 fuel stock at sea reducing the logistics tail on fuel delivery with no environmental burden and increasing the Navy's energy security and independence," says research chemist, Dr. Heather Willauer.

NRL has successfully developed and demonstrated technologies for the recovery of CO₂ and the production of H₂ from seawater using an electrochemical acidification cell, and the conversion of CO₂ and H₂ to hydrocarbons (organic compounds consisting of hydrogen and carbon) that can be used to produce jet fuel.

"The reduction and hydrogenation of CO₂ to form hydrocarbons is accomplished using a catalyst that is similar to those used for Fischer-Tropsch reduction and hydrogenation of carbon monoxide," adds Willauer. "By modifying the surface composition of iron catalysts in fixed-bed reactors, NRL has successfully improved CO₂ conversion efficiencies up to 60 percent."

A Renewable Resource

CO₂ is an abundant carbon (C) resource in the air and in seawater, with the concentration in the ocean about 140 times greater than that in air. Two to three percent of the CO₂ in seawater is dissolved CO₂ gas in the form of carbonic acid, one percent is carbonate, and the remaining 96 to 97 percent is bound in bicarbonate. If processes are developed to take advantage of the higher weight per volume concentration of CO₂ in seawater, coupled with more efficient catalysts for the heterogeneous catalysis of CO₂ and H₂, a viable sea-based synthetic fuel process can be envisioned. "With such a process, the Navy could avoid the uncertainties inherent in procuring fuel from foreign sources and/or maintaining long supply lines," Willauer said.

NRL has made significant advances developing carbon capture technologies in the laboratory. In the summer of 2009 a standard commercially available chlorine dioxide cell and an electro-deionization cell were modified to function as electrochemical acidification cells. Using the novel cells both dissolved and bound CO₂ were recovered from seawater by re-equilibrating carbonate and bicarbonate to CO₂ gas at a seawater pH below 6. In addition to CO₂, the cells produced H₂ at the cathode as a by-product.

These completed studies assessed the effects of the acidification cell configuration, seawater composition, flow rate, and current on seawater pH levels. The data were used to determine the feasibility of this approach for efficiently extracting large quantities of CO₂ from seawater. From these feasibility studies NRL successfully scaled-up and integrated the carbon capture technology into an independent skid to process larger volumes of seawater and evaluate the overall system design and efficiencies.

The major component of the carbon capture skid is a three-chambered electrochemical acidification cell. This cell uses small quantities of electricity to exchange hydrogen ions produced at the anode with sodium ions in the seawater stream. As a result, the seawater is acidified. At the cathode, water is reduced to H₂ gas and sodium hydroxide (NaOH) is formed. This basic solution may be re-combined with the acidified seawater to return the seawater to its original pH with no additional chemicals. Current and continuing research using this carbon capture skid demonstrates the continuous efficient production of H₂ and the recovery of up to 92 percent of CO₂ from seawater.

Located at NRL's Center for Corrosion Science & Engineering facility, Key West, Fla., (NRLKW) the carbon capture skid has been tested using seawater from the Gulf of Mexico to simulate conditions that will be encountered in an actual open ocean process for capturing CO₂ from seawater and producing H₂ gas. Currently NRL is working on process optimization and scale-up. Once these are completed, initial studies predict that jet fuel from seawater would cost in the range of $3 to $6 per gallon to produce.

How it Works: CO₂ + H₂ = Jet Fuel

NRL has developed a two-step process in the laboratory to convert the CO₂ and H₂ gathered from the seawater to liquid hydrocarbons. In the first step, an iron-based catalyst has been developed that can achieve CO₂ conversion levels up to 60 percent and decrease unwanted methane production from 97 percent to 25 percent in favor of longer-chain unsaturated hydrocarbons (olefins).

In the second step these olefins can be oligomerized (a chemical process that converts monomers, molecules of low molecular weight, to a compound of higher molecular weight by a finite degree of polymerization) into a liquid containing hydrocarbon molecules in the carbon C₉-C₁₆ range, suitable for conversion to jet fuel by a nickel-supported catalyst reaction.

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CT scan and 3-D print help scientists reconstruct an ancient mollusk

ScienceDaily (Sep. 19, 2012) ? Using a combination of traditional and innovative model-building techniques, scientists in the U.S. and a specialist in Denmark have created a lifelike reconstruction of an ancient mollusk, offering a vivid portrait of a creature that lived about 390 million years ago, and answering questions about its place in the tree of life, as described in the Sept. 18 edition of the journal Palaeontology.

The model of the oval-shaped sea creature, called a multiplacophoran, which was covered with stiff plates and a ring of spines, resulted from a collaboration between Jakob Vinther, a postdoctoral researcher at The University of Texas at Austin's Jackson School of Geosciences, and Esben Horn, owner of the model making company 10 Tons in Copenhagen (http://www.10tons.dk), with animation help from Ryan Carney, a doctoral student at Brown University.

Working with a delicate specimen of a multiplacophoran partially covered by rock, Vinther used a micro CT scan -- a noninvasive technology similar to medical CAT scanning -- to create a three-dimensional view of the fossil. With Carney's help, the CT scan yielded an animated view of the original placement of the creature's dense spines and shells, which had splayed out and decayed prior to fossilization.

The CT scan also produced a three-dimensional cast of the specimen in its reconstructed shape. Working with the cast, the animation and information on living relatives of the multiplacophorans, Horn was able to create a multicolored, textured model in clay, resin and silicone showing how the creature looked millions of years ago, when it crawled on a single, suction-like foot over shells and rocky surfaces in ancient oceans.

The model helps address a debate about how multiplacophorans (which were only discovered in the past decade) relate to chitons, another more widely known plated mollusk that lives on seashores and is commonly eaten in the Caribbean. By dating the origin of modern chitons, Vinther could demonstrate that multiplacophorans are stem group chitons.

"We can now demonstrate that multiplacophorans are distant relatives of the modern chitons, which did not evolve until later in Earth history," said Vinther. "We can also show that they evolved a number of characteristics seen in some modern chitons convergently."

The CT scan was integral to the project, allowing the scientists to see below the surface of the fossil.

"CT scanning is an extremely powerful technique for paleontologists," said Vinther, "since we can look inside fossils without destroying them."

The original fossil was discovered 10 years ago in Ohio by private collector and co-author George Kampouris, who donated it to the Cincinnati Museum of Natural History.

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Journal Reference:

1. Jakob Vinther, Peter Jell, George Kampouris, Ryan Carney, Rachel A. Racicot, Derek E. G. Briggs. The origin of multiplacophorans - convergent evolution in Aculiferan molluscs. Palaeontology, 2012; 55 (5): 1007 DOI: 10.1111/j.1475-4983.2012.01180.x

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/BRMxucD4HJ0/120919125742.htm

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