As The Big Wedding hits theaters, take a look back at the most lavish celebrity nuptials. Bring on the champagne and caviar!
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As The Big Wedding hits theaters, take a look back at the most lavish celebrity nuptials. Bring on the champagne and caviar!
survivor snl peter frampton Sandy Hook Elementary School Colors Cassadee Pope Victoria Soto nbc sports

The Apple Store app for iPhone has been updated with a handy little feature that will notify you when you're eligible for upgrade pricing on a new iPhone. You can even buy your new iPhone directly with the app after receiving the notification since all you need is your Apple ID credentials to do so.
Also, the Apple Store will now help you keep track of your shipments and send you notifications about important updates, and when it has delivered.
Anyone waiting for upgrade eligibility before buying the iPhone 5? Are you excited about being notified when that day comes?
Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/9rhvbS8v_Co/story01.htm
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Even with $145 billion in its back pocket, Apple isn't above the odd bit of cost-saving. Following rumors that its new campus was $2 billion over budget, the company has revised its plans for the facility. While the UFO-style HQ is untouched, a secondary complex that was to be built along North Tantau Ave. has been pushed back to phase two -- which means it'll begin construction in 2016, just after people start working in the spaceship.
Filed under: Apple
Via: MacRumors
Source: Apple (.PDF)
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/zPCTi747ncM/
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INDIANAPOLIS (AP) ? Pacers forward Paul George spent the past summer turning himself into a better player.
Now he's planning to dedicate himself to becoming the NBA's best all-around player.
A few minutes after accepting the league's Most Improved Player Award, the 6-foot-9 swingman promised to work even harder to attain the biggest rewards of all ? an NBA title and perhaps an MVP.
"I think I can play at an MVP level. I think that's very much within reach," George said Tuesday. "For me, it's all about being consistent and having that aggressive mindset."
George has already emerged as one of the league's top young players, which explains his runaway victory in the balloting. He received 52 of 120 first-place votes and 311 points, more than double the total of New Orleans' Greivis Vasquez, who had 13 first-place votes and 146 points. Milwaukee's Larry Sanders was third with 141 points and was one of three players to receive 10 first-place votes.
As part of the award, a 2012 Kia Sorrento will be donated to the Hawthorne Community Center, George's hand-picked charity.
George is also expected to be one of the top vote-getters for the Defensive Player of the Year Award, an honor coach Frank Vogel lobbied hard for Tuesday.
The question is whether George has what it takes to challenge for the league's top individual honor.
"With the physical talent he has, with the drive he has, there's no ceiling for him," Vogel said.
If 2012-13 proved anything, it's that George is a man of his word.
Before leaving town after last season's Eastern Conference semifinal loss to LeBron James and eventual champion Miami, George walked into Vogel's office and promised to come back with a more aggressive mindset and as a more versatile scorer.
LeBron James' guidance helped him reach those goals.
The two worked out together in Las Vegas as the U.S. team prepared for the Olympics, but all the while George was watching and learning from the best ? not just James.
"It was huge. Me, growing up, idolizing guys like Kobe, watching his whole regimen, watching what time he got up to work out, watching what he was putting in his body," George said. "The younger guys, we was totally the opposite, so I had to kind of take notes and follow what they were doing."
The results impressed his teammates, coaches and many around the league.
George averaged 17.4 points and 7.6 rebounds this season, both career highs, and was the only player in the league with at least 140 steals and 50 blocks. He earned his first All-Star appearance, led Indiana to its first Central Division crown in nine years and became the fourth Pacers player to win the Most Improved Player Award since 2000. The others were Jalen Rose, Jermaine O'Neal and Danny Granger.
In 2011-12, George averaged 12.1 points and 5.6 rebounds and made just 19 of 52 shots from the field in the 4-2 playoff loss to the Heat.
Granger, for one, isn't surprised by George's success.
"I was working out with Paul and a couple of other players about five days before the (2010) draft and Larry Bird called and asked me what I thought about him. I told him, 'You better draft him,'" Granger said. "Sometimes you have talent viewing players and seeing what they can do for a team. He had that talent and, at 6-9, Paul possesses a lot of ability a lot of guys don't have."
The announcement came less than 48 hours after George played his most complete game of the season. He joined Mark Jackson as the only players in franchise history to record a triple double in the NBA playoffs. George finished with 23 points, 11 rebounds and 12 assists in the Pacers' 107-90 Game 1 win over Atlanta ? giving Indiana its first 1-0 series lead since 2006. Game 2 is Wednesday night in Indy.
After showing steady improvement through each of his first two NBA seasons, George finally got his chance to lead when Granger went down with a left knee injury. Granger, Indiana's top scorer the previous five seasons, played in only five games.
So George took it upon himself to make up for the absence.
"He's a rare breed with his purity for the game and his willingness to play team basketball at both ends of the court and his drive to get better," Vogel said. "I think he was ready to explode whether Danny was in or out."
Despite shooting just 3 of 13 from the field Sunday, George made his first 17 foul shots to tie Reggie Miller's postseason mark for best free-throw percentage in a single game, then missed his 18th and final attempt.
Soon he was picking up his first big award.
He doesn't expect it to be his last.
"A lot of players don't get an opportunity to make the playoffs and have a team that can win the championship," George said. "Coach says all the time that this could be your last time in the playoffs. So I've really not focused on where I need to get better or thought about the offseason yet."
Source: http://news.yahoo.com/pacers-paul-george-wins-nbas-most-improved-award-141333154--spt.html
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Apr. 23, 2013 ? With their whiskers rats can detect the texture of objects in the same way as humans do using their fingertips. A study, in which some scientists of SISSA have taken part, shows that it is possible to understand what specific object has been touched by a rat by observing the activation of brain neurons. A further step towards understanding how the brain, also in humans, represents the outside world.
We know the world through the sensory representations within our brain. Such "reconstruction" is performed through the electrical activation of neural cells, the code that contains the information that is constantly processed by the brain. If we wish to understand what are the rules followed by the representation of the world inside the brain we have to comprehend how electrical activation is linked to the sensory experience. For this reason, a team of researchers including Mathew Diamond, Houman Safaai and Moritz von Heimendahl of the International School for Advanced Studies (SISSA) of Trieste have analyzed the behavior and the activation of neural networks in rats while they were carrying out tactile object recognition tests.
During the experiments researchers observed the performance of rats -- the animals were discriminating one texture from another -- along with the activation of a group of sensory neurons. "For the first time the study has monitored the activity of multiple neurons, while until now, due to technical limitations, researchers had examined only individual neurons," explains Diamond, who heads up the Tactile Perception and Learning Lab at SISSA. "The activity of such groups of neurons is represented in our model as multi-dimensional clouds, comprising as many dimensions as the number of cells under examination (up to ten). We have observed a different cloud for the contact with each different texture."
By analyzing the "clouds," Diamond and his colleagues were able to successfully decode the object contacted by the rodent. "Our method is so accurate that when the rat would mistake one object for another, the decoding would also indicate a different object from the one actually touched. And this happened because the representation made by the brain -- and, as a consequence, our decoding -- appeared like that of a different object. Hence the error."
Diamond's team has no intention of stopping here. "In real life, we generally recognize objects using more senses all together, in an integrated manner. We use touch and sight at the same time, for instance," explains Diamond. "For this reason we are now working on new experiments employing more neurons, with more complicated stimuli, and more senses, to build 'multimodal' representations of objects."
This kind of "mind reading" carried out on rats' brain by Diamond and his colleagues is important to understand how the brain forms a representation of the world. "Each one of us perceives a physical world outside ourselves, yet actually all we have at our disposal to create an experience of the world is the representation that our brain makes of it through the input of sensory organs" says Diamond.
To understand that such a representation is at the very least partial it is enough to think of all the information about the world that escapes us all the time: for instance, we are blind to infrared and ultraviolet rays, we are unable to hear certain sound frequencies or smell some chemical substances or others. Some details pertaining to the physical world are completely invisible or, to put it better, imperceptible (others are interpreted incorrectly, like visual illusions, for example.)
This is a further demonstration that what we perceive is not the physical world in itself, but the neuronal activation the world evokes inside our brain.
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TORONTO (AP) ? A man accused of plotting with al-Qaida members in Iran to derail a train in Canada was due to appear in a Toronto court Wednesday after declaring at his initial court appearance that the charges against him are unfair. Law enforcement officials in the U.S. said the target was a train that runs between New York City and Canada.
Canadian investigators say Raed Jaser, 35, and his suspected accomplice Chiheb Esseghaier, 30, received guidance ? but no money ? from members of al-Qaida in Iran. Iran released a statement saying it had nothing to do with the plot, even though there were no claims in Canada that the attacks were sponsored directly by Iran.
In a brief court appearance in Montreal, a bearded Esseghaier declined to be represented by a court-appointed lawyer. He made a brief statement in French in which he rejected the allegations against him.
"The conclusions were made based on facts and words which are only appearances," he said in a calm voice after asking permission to speak.
Esseghaier, who was arrested Monday afternoon at a McDonald's restaurant in the train station, was later flown to Toronto for a court appearance Wednesday in the city where his trial will take place.
Jaser appeared in court earlier Tuesday in Toronto and also did not enter a plea. He was given a new court date of May 23. He had a long beard, wore a black shirt with no tie, and was accompanied by his parents and brother. The court granted a request by his lawyer, John Norris, for a publication ban on future evidence and testimony.
The case has raised questions about the extent of Shiite-led Iran's relationship with al-Qaida, a predominantly Sunni Arab terrorist network. It also renewed attention on Iran's complicated history with the terror group, which ranges from outright hostility to alliances of convenience and even overtures by Tehran to assist Washington after the Sept. 11, 2001, attacks on the United States.
"We oppose any terrorist and violent action that would jeopardize lives of innocent people," Iranian Foreign Ministry spokesman Ramin Mehmanparast said Tuesday.
Charges against the two men in Canada include conspiring to carry out an attack and murder people in association with a terrorist group. Police ? tipped off by an imam worried by the behavior of one of the suspects ? said it was the first known attack planned by al-Qaida in Canada. The two could be sentenced to life in prison if convicted.
Law officials in New York with knowledge of the investigation told The Associated Press the attack was to take place on the Canadian side of the border. They are not authorized to discuss the investigation and spoke only on condition of anonymity.
Amtrak and Via Rail Canada jointly operate routes between the United States and Canada, including the Maple Leaf from New York City to Toronto.
Mayor Michael Bloomberg said Canada has kept New York posted on the investigation.
"I can just tell you that you are probably safer in New York City than you are in any other big city," Bloomberg told reporters Tuesday without discussing details.
Jaser's lawyer said his client questioned the timing of the arrests, pointing to ongoing debates in the Canadian Parliament over a new anti-terrorism law that would expand the powers of police and intelligence agencies.
Norris speaking outside the court said his client is "in a state of shock and disbelief."
He said his client would "defend himself vigorously" against the accusations, and noted Jaser was a permanent resident of Canada who has lived there for 20 years. Norris refused to say where Jaser was from, saying that revealing his nationality in the current climate amounted to demonizing him.
Canadian police also declined to release the men's nationalities, saying only they had been in Canada a "significant amount of time."
Muslim community leaders who were briefed by the Royal Canadian Mounted Police ahead of Monday's announcement of the arrest said they were told one of the suspects is Tunisian and the other from the United Arab Emirates.
But the United Arab Emirates embassy in Ottawa said in a statement Tuesday that neither of the two men were UAE nationals.
Esseghaier's LinkedIn profile lists him as having studied in Tunisia before moving to Canada, where he was pursuing a Ph.D. in nanotechnology at the National Institute of Scientific Research, a spokeswoman at the training university confirmed.
The investigation surrounding the planned attack was part of a cross-border operation involving Canadian law enforcement agencies, the FBI and the U.S. Department of Homeland Security. Canadian police said the men never got close to carrying out the attack.
The warning first came from an imam in Toronto, who in turn was tipped off by suspicious behavior on the part of one of the suspect.
"I was involved in alerting police about the suspect. I made some calls on behalf of the imam over a year ago," Toronto lawyer Naseer Syed said. He would not say what, exactly made the imam suspicious.
"The Muslim community has been cooperating with authorities for a number of years and people do the right thing when there is reason to alert authorities," Syed said, adding that he was speaking for the imam, who wished to remain anonymous.
___
Associated Press writers Charmaine Noronha in Ontario, Shingler in Montreal, Tom Hays and Jennifer Peltz in New York, Kimberly Dozier in Washington and Brian Murphy in the United Arab Emirates contributed to this story.
Source: http://news.yahoo.com/suspect-canada-terror-plot-denies-charges-220238197.html
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Scientists from The University of Manchester have identified 14 new genes which could have important consequences for future treatments of childhood arthritis. Scientists Dr Anne Hinks, Dr Joanna Cobb and Professor Wendy Thomson, from the University's Arthritis Research UK Epidemiology Unit, whose work is published in Nature Geneticsyesterday, looked at DNA extracted from blood and saliva samples of 2,000 children with childhood arthritis and compared these to healthy people.
Principal Investigator Professor Thomson, who also leads the Inflammatory Arthritis in Children theme at the National Institute for Health Research (NIHR) Manchester Musculoskeletal Biomedical Research Unit, said: "This study brought together an international group of scientists from around the world and is the largest investigation into the genetics of childhood arthritis to date."
Childhood arthritis affects one in 1,000 in the UK. It is caused by a combination of genetic and environmental risk factors, however until recently very little was known about the genes that are important in developing this disease ? only three were previously known.
Dr Hinks, joint lead author of the study, said the findings were significant for understanding more about the biology of the disease and this might help identify novel therapies for the disease. "Childhood arthritis, also known as juvenile idiopathic arthritis (JIA), is a specific type of arthritis quite separate from types found in adults and there's been only a limited amount of research into this area in the past," she said. "This study set out to look for specific risk factors. To identify these 14 genetic risk factors is quite a big discovery. It will help us to understand what's causing the condition, how it progresses and then to potentially develop new therapies."
The study may help to predict which children need specific treatment earlier and allow health workers to better control their pain management, quality of life and long-term outcome. Currently 30 per cent of children with the disease continue to suffer from arthritis in adulthood.
Dr Cobb, joint lead author, added: "There are lots of different forms of childhood arthritis so identifying the markers will help us understand a little bit more about the disease process. It will also help to categorise children with JIA into sub-types dependent on which genes they have and allow us to determine the best course of treatment."
The study which took two years to complete, will ultimately help clinicians to better manage children with the disease and give potential to develop new therapies.
Professor Alan Silman, medical director of Arthritis Research UK who part funded the work, said: "We have known for some time that there is a strong genetic contribution to a child's risk of developing JIA, however previously only three genetic risk factors had been identified. This study is the largest genetic investigation of JIA to date and has identified 14 new risk regions, adding a significant amount to our knowledge of the genetic basis of this disorder. Further work is now required to investigate each of these regions in more detail, to enable us to understand how they are involved in disease development and identify potential new therapeutic targets."
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University of Manchester: http://www.manchester.ac.uk
Thanks to University of Manchester for this article.
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Source: http://www.labspaces.net/127864/Discovery_of_new_genes_will_help_childhood_arthritis_treatment
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